Controlling hyperlipidemia is one of the fundamental preventions of cardiovascular diseases. In this study, the lipid lowering activity of ethanolic extract of Luffa acutangula with treatment concentrations of 50%, 75%, and 100% were tested in hypercholesterolemic-induced albino rats. Six albino rats in triplicates were acclimatized for a week and were given buttered pellets as their high-fat diet. The test organisms were divided into three groups and after a four-week treatment, the weights were recorded, collection and analysis of blood for the lipid profile – triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) took place. At the end of the study, the extract was proven to be ineffective for weight loss but has lowered the lipid profile. In respect to the baseline values, the highest reduction of 4.9 mg/dl, 16.92 mg/dl, and 21.79 mg/dl for HDL, LDL and TC, respectively, were observed. Statistically, results showed that there is no significant
