The Effects of Flooding on Amassoma Flood Plain benthic macro-invertebrates in the Niger Delta area of Nigeria was studied for a period of six months (November – December, 2012 and January, 2013 for the dry season and April, May and June; 2013 for the Wet season) and compared with results obtained from similar studies. A total of Twenty-seven (27 benthic macro-invertebrate species belonging to fourteen (14) families were present in both before and after flooding. These include: NAIDIDAE: Ophisdonias serpentine, Dera sp, Paranais sp, Uncinais uncinata and Styleria lacustris; LUMBRICIDAE: Eiseniella tetrahida and Lumbricus variegates; NEREIDAE: Nereis virens, Nereis diversicolor and Nereis pelagic; CAPITELLIDAE: Nephthys hombergi; CAPITELLIDAE: Capitella capitta, Notomastus tenuis and Notomastus latericeus; EUNICIDAE: Marphysa sp; GLYCERIDAE: Glycera capitata and Glycera convolute; ARENICOLIDAE: Arenicola marina and Polydora capensis; SYLLIDAE: Syllis profera; GAMMARIDAE: Gammarus lacustra; PANAIDAE: Paneus notialis; CHIRONOMIDAE: Chironomous sp; POTAMIDAE: Tympanotosonus fuscatus and Pachmelania fusca and TELLIDAE: Tellina nymphalis, Loripes sp and Tegalus andersoni. Benthic macro-invertebrate population also increased significantly after the flooding though there was no significant variation between sampling stations.