The Aim of this research was to survey effect of exercise training intensity and volume changes on Maximal Oxygen Uptake ( O2 max) and resting HR. For this purpose 45 non athletic health undergraduate students with means 25±1.87 year, weight 71±1.95 Kg and height 175±2.30 voluntarily contributed at this research. Subjects randomly divided into four groups that were included group of moderate (50-55% HRR, N=12, group 1), Low vigorous (60- 65% HRR, N=12, group 2), high vigorous intensity (70-75% HRR, N=12, group3) or a non-exercising control group (N=10, group 4). In first six weeks, group 1 run on treadmill for 30 minutes and with intensity of 70 % heart rate reserve (HRR), group 2 run for 30 minutes and with intensity of 60% HRR and group 3 run for 30 minutes and with intensity of 50% HRR, and in two last weeks, group 1 run on treadmill with intensity of 75% HRR, group 2 with intensity of 65% HRR, and group 3 with intensity of 55% HRR. For analysis of findings used ANOVA test and Tukey test (P=0.05). Findings showed that there is significant difference in O2 max change in group 1 and group 3. Also Group 3 made more reduction in resting heart rate than group 1. Base on findings of current research, it deducted that for raise of O2 max, three sessions training in week with intensity of 50-55% HRR has more effects rather than one session training in week with intensity of 70-75% HRR.