The present study aims at determination of effect of strength training on blood lipid profile and hormonal responses of testosterone and cortisol in young Greco Roman wrestlers.Methods: 8 young male Greco Roman wrestlers with mean age of 20.50±1.195 were selected voluntarily. Strength training consisted of 8 weeks of strength training with 55% of one repeated maximum (1RM) in 2 times with 10 repetitions which reached 85% 1RM in the eighth week in three times with 6 repetitions. Concentrations of sub factors (i.e. lipid, testosterone and cortisol of blood serum) were measured in pre-test, end of fourth week, and end of eighth week at 8 in the morning. Data analysis was performed through within group variance analysis with iterative amounts in three stages and Kolmogorov-Smirnov Test was adopted for normality of the data; also, significance level was set to be p≤0.05. Results: no significance difference was detected in LDL-C, TG, TC, COR, TT and TC: HDL-C (p>0.05). However, HDL-C concentration in the subjects of strength group showed a significance difference (p<0.035).Conclusion: decreased concentration of HDL-C and increased serum testosterone caused by 8 weeks of strength training in young Greco Roman wrestlers may be effective in appearance of cardiovascular diseases (CVD); intensity of the influence in a function of training duration and other related factors to training program.