Medication through an enteral feeding tube is one of the main cares in patients hospitalized in the intensive care unit continuously being a challenge. Correct delivery of medication through an enteral feeding tube requires specific knowledge and skills in this field. The nurse as the main responsible for administering a drug, has a very important role in this regard. This study was carried out as a quasi-experimental study on 90 cases of ICU nurses. First, using a questionnaire (pretest), the level of knowledge and practice in intensive care unit was measured. The training course for speech, along with a pamphlet and face to face, was held and again after a month their awareness and performance was measured by questionnaire (post-test).For analysis of data, SPSS software (version 21) and paired tests and chi-square was used. Results showed the mean score of nurses' knowledge prior to applying scientific principles (12/9889 ±2/04167) and their knowledge after that (19/3333±0/71893); mean performance score prior to applying scientific principles was significantly difference with the average score of their next performance (P=0/0001). Also results indicated that the average of all subscales of knowledge and practice (preparation, dosage forms, thumbs up and tubal obstruction, drug interactions and side effects) significantly increased after the application of scientific principles (P=0/0001). This study showed that the application of scientific principles in accordance with the instructions provided, significantly increases knowledge and practice of nurses.
