The crude extract from Sacoglottis gabonensis (Urban Humiriaceae) stem bark was prepared using standard method. The jejunum of the rabbit was obtained through dissection. About 2-3cm3 of the isolated jejunum was mounted in an organ bath containing Tyrode solution at 37oc ±1oc.These investigation was carried out on the isolated jejunum. Result showed that the extract induce relaxation effect on the intestinal motility of the isolated rabbit jejunum, whereas the standard drug acetylcholine induced contraction effect. The log- dose response curve for the extract shows that at higher concentration of the added extract the response is lower, while in the case of the standard drug, the trend was reversed, thus increase in drug concentration increases the intestinal motility of the isolated rabbit jejunum, with increase in amplitude. From the result it is likely that the extract may cause diarrhea and the standard drug causes constipation.
