Regular exercise reduces functional loss associated with multiple sclerosis (MS). However, the impact of exercise on
cytokines associated with disease activity remains relatively unexplored. The aim of this study was to examine the
effects of 8 weeks resistance training (RT) on IL-16 and IL-10 levels in female patients with MS. Twenty seven
female with MS disease in a range of 18-48 year of old and EDSS lower than 4.5 participated in this study as the
subject. Subjects were divided into control group (n=13) or training group (n=14) randomly. The training group
performed progressive RT program, 3 days a week for 8 weeks. The control group was in absolute rest at the same
time. The results showed that although after eight weeks of RT, IL-6 decreased and IL-10 increased in the exercise
group but these changes did not achieve statistical significance. The results suggest RT with specific intensity and
duration utilized in this study had not significant effect on IL-16 and IL-10 levels in female patients with MS.
