High salt loading is associated with myriad cellular damage, hypertension and death. It is not known if Masfon aloe vera gel could ameliorate the menace of high salt loading. This study aimed to investigate the effect of Masfon aloe vera gel on some blood parameters in high salt loaded rats. Twenty four (24) albino Wistar rats were randomly assigned into 4 groups of 6 rats each. The rats took either on normal rat chow, high salt (8% NaCl feed + 1% NaCl drinking water) diet and/or Masfon aloe vera gel 6 weeks. Blood samples obtained into EDTA sample bottles for full blood counting using automated blood counter. RBC and total WBC counts increased significantly (p<0.05) in the tests groups compared to the control. The control values of RBC and total WBC were 6.07 ±0.24 x103/μL and 7.01 ±0.11 x106/μL. The Hb concentration in the control was 12.80 ±0.20g/dL, it was significantly (p<0.05) raised in the salt treated (ST) group compared with other groups. PCV increased significantly (p<0.05) in the salt fed untreated (SF) and ST groups compared with control. The normal treated (NT) group had significant (p<0.05) increase in platelet count compared with other groups, but their red cell distribution width was significantly (p<0.05) reduced compared with other groups. Mean corpuscular volume (MCV) did not later significantly among the groups, but the mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) decreased significantly (p<0.05) in SF group compared with other groups. Lymphocytes count increased, while neutrophils decreased significantly (p<0.05) in all the tests groups compared with the control. PDW, MPV and P-LCR decreased significantly in the extract treated groups (NT and ST) compared with other groups. In conclusion, high salt loading and treatment with Masfon aloe vera gel increased the total WBCs, lymphocytes, RBCs, Hb and PCV. However, Masfon aloe vera reversed elevated PDW, MPV and P-LCR and the low MCH and MCHC induced by high salt loading in rats.
