Cymbopgoncitratus is well known for its extensive use in folk medicine. Its essential oils and extracts have been shown to have antimalarial, antileshmanial, hypolipidemic, hypoglycemic, antioxidant, anti-inflammatory, antifungal and antibacterial activities amongst others. This study was carried out to assess the effect of long-term oral administration of the aqueous and ethanol leaf extracts on some biochemical and metabolic parameters in experimental animals. Systemic acute oral toxicity was assessed in mice up to a dose of 5gKg-1BW, while the subacute and sub-chronic toxicity were studied on wistar rats. Graded doses of 0.25, 0.5 and 1gKg-1BW of each extract were administered to experimental groups of rats for a period of 28 days and 90 days respectively, while the control groups received the vehicle. Acute oral toxicity of the extracts did not produce any mortality or adverse signs of toxicity. The extracts did not have any adverse effect in changes in calculated body/organs weights and the hematopoietic system of rats. However, assay on some biochemical parameters revealed mild toxicity of the liver and kidneys at the highest dose for both extracts. The extracts demonstrated strong hypolipidemic and hypoglycemic activities, which could associate it with the management of artherosclerotic diseases and increased blood sugar levels.
