The aim of the present study involves the effect of Fluoxetine and Escitalopram on hypoglycemic response of repaglinide. The whole data was obtained from the albino rats which are treated with Repaglinide along with antidepressant drugs like Fluoxetine &Escitalopram to observe their drug interactions in diabetic rats. The individual drugs were tested on healthy &diabetic induced albino rats to conform their effect on hypoglycemic activity. Fluoxetine, Escitalopram had shown no alterations in blood glucose levels when it is administered to healthy rat. Repaglinide had reduced blood glucose levels upto 6hours.Effect of treatment of Fluoxetine &Escitalopram on the hypoglycemic activity of Repaglinide in healthy albino rats had shown marked decrease in blood glucose levels. Fluoxetine and Escitalopram on blood glucose levels in diabetic albino rats did not show any alterations. Repaglinide had shown activity on decreasing the blood glucose levels in diabetic albino rats. Fluoxetine and Escitalopram had markedly reduced the hypoglycemic effect of Repaglinide in diabetic rats with out any change in duration of action. The present study indicates that Fluoxetine and Escitalopram have effect on hypoglycemic activity of Repaglinide.Both Fluoxetine &Escitalopram did not show any changes in glucose levels of normal albino rats. But they both increased the reduction of blood glucose levels of Repaglinide by 30 min in healthy rats& diabetic rats.
