The aim of the present research was to determine the effect of exercise at different times of day on the inflammatory markers which make the risk of coronary heart diseases in obese men. 40 non-athletes, obese men (age mean 22.25±2.5 and weight mean 89.74±6.07) were randomly allocated to four groups of morning and evening aerobic training and morning and evening control. Morning and evening training groups performed the aerobic training protocol three sessions per week for 12 weeks while the control groups were denied doing training programs during the research period. Blood samples (5 cc) were taken from the participants at the beginning of the period, week 6 and end of week 12 in order to measure C-reactive protein (CRP), interlukin-6 (IL-6) and tumor necrosis factor-alpha (TNF- α). The results showed that morning and evening aerobic training decreased CRP (p=0.002) and IL-6 (p= 0.001) in the experimental groups compared with the control ones. Also, the amount of produced inflammatory markers was less in the evening than in the morning (in the evening training group, the amount of CRP was 17.1%, 10.5% and 18.87% in week 1, week 6 and week12 and the amount of IL-6 was respectively 21.5%, 16.74% and 25.32% lower than that of the morning training group). According to the results of this study, it was determined that different times of the day influence the compatibility of inflammatory markers caused by aerobic training and these markers show more reduction in the evening. Therefore, it is recommended to young obese men to do exercises in the evening rather than morning.
