This aim of the experiment is to evaluate the effect of ethanolic extract of Caralluma diazielli on Serum electrolytes levels on fructose-induced diabetes in Wistar rats. Induction of diabetes was done by dissolving 20g/100ml (20%) of fructose in distilled water. After which the animals were randomly assigned into 5 groups of 5 rats each. Group 1 negative control received distilled water( 5mg/kg), Group 2 received positive control received glibenclimide orally (1mg/kg b w), Group 3 received 200mg/kg b w of extract of C.diazielli orally, Group 4 received 100mg/kg b w of extract of C.diazielli orally Group 5 received 50mg/kg b w of extract of C.diazielli orally. The results obtained showed statistical significant reductions (p<0.05) in levels of serum sodium (Na+) and serum potassium(K+) all the tested doses when compared with the control untreated group. However there is no statistical significant in the serum level of chloride (Cl- when compared with the control untreated group. In relation to the serum level of bicarbonate (HCO3) there was a significant decrease in the groups treated with the extract of C.diazielli when compared to control group, while there was no significant change in the group treated with the standard drug (Glibenclimide). The preliminary phytochemical screening of C.diazielli revealed the presences of cardenolides carbohydrate flavonoid and glycosides. Also the Acute toxicity of the extract was found to be 2.154 mg/kg orally.
