The treatment of type 2 diabetes mellitus has been a great challenge, especially in developing countries. Thus the need for plant based substitutes to overcome this problem is necessary due to the side effects of synthetic antidiabetic drugs. Three doses of the extract Caralluma dalzielii 50, 100 and 200mg/kg B.w. were administered orally to fructose induced types 2 diabetes in Wistar rats . The dose of 50mg/kg bodyweight when administered to diabetic rats, produced an appreciable hypoglycemic effect with (-14.13%) glycemic decrease. Also the standard reference drug glibenclimide produced hypoglycemic effect with (-9.78%) glycemic decrease after 3 days of treatment (p<0.05). As regards the other two doses of the extract, the doses 100 and 200 mg/kg bodyweight produced no significant change in the of blood glucose levels after 3,6 and 9 days of administration, while the least dose of 50mg/kg bodyweight produced a significant decrease (p<0.05) after 9 days of extract administration with glycemic decrease of (-16.31%.)In conclusion, the dose of 50 mg/Kg of the extract has shown both significant (p<0.05) hypoglycemic and anti-hyperglycemic effects in Wistar rats.
