The aim of this study was the effect of 12 weeks endurance and resistance training on C - reactive protein in obese children. For this purpose 16 obese children (BMI> 28, age= 11-13 year old) were voluntarily participated in this study. Obese children were randomly divided into two groups: experimental (n= 8), and control (n= 8). Blood sample were taken in two stages (before and after completion of 12 weeks) as well as 12-14 hours after fasting. Serum was kept at -80°c until C-reactive protein analysis. Experimental groups received 12 weeks endurance and resistance trainings (3 sessions per week). Intensity of the resistant training was based on previously maximum repeated exercises. Intensity of theEndurance training was based on the maximum heart rate (HRmax) estimated by: 220 _ age (at 12th week heart rate increased up to 80% - 85% of HRmax). Results showed that 12 weeks endurance and resistance training caused to significant decrease of the C-reactive protein levels,body fat mass, and body mass index in experimental group compared to the control group (p<0.05). It is suggested that regular participation in endurance and resistance training program can be associated with decreased future cardiovascular risk inthe obese children, as well as it is a goalfor behavior change in both prevention and treatment of childhood obesity.