The plant use as a immunomodulator namely Andrographis paniculata, Momardica charantia, Phyllanthus niruri, Terminallia chebula, Glycyrrhiza glabra, Punica granatum. It has good impact in the treatment and management of HIV-AIDS because these plant not only treats disease but also enhance the body vitality and immunity. The humoral and cell-mediated immune response was observed through Delayed Type Hypersensitivity (DTH) model. This formulation has studied on swiss albino mice in normal and suppressed immune system by Cyclophosphamide (CP) in formulation (F1) and (F2) doses it shown maximum decrease in foot paw oedema from 2.15mm to 0.35 mm, similarly maximum increase in the WBC and Platelet count upto 10.4±0.07 thousand / mm3 and 96142 ±142 in (F1) respectively. It shown significant statistical analysis P<0.001.
