The objective of present study is to investigate anti-ulcer activity of Artocarpus heterophyllus Lam. leaves extracts on indomethacin induced ulcers in rats and establish the probable mechanism of antiulcer activity, if any and confirm the validity of claims of the activity as mentioned in texts as traditional medicines. The leaves were extracted with methanol and anti-ulcer activity was evaluated for effects on indomethacin-induced gastric ulceration on Swiss albino rats. The various parameter used to assess anti-ulcer activity were pH of gastric contents, concentration of acid in gastric contents and gastric ulcer scoring in indomethacin- induced ulcer model. The methanolic extract (500 mg/kg, p.o.) exhibited inhibition of indomethacin-induced gastric ulceration, decreasing concentration of acid in gastric content and increasing pH of gastric contents. Acute toxicity study showed that there was no mortality after the application of extract in doses above 5000mg/kg. The anti-ulcer property probably acts via a reduction in gastric acid secretion.
