A study of the effect of aqueous extract (10%w/v) of the leaves of Acalypha wilkesiana (a popular medicinal plant used in Nigeria for the treatment of fever in infants) was studied in the liver and kidney of albino rats. The activities of Alkaline Phosphatase (ALP), Alanine Transaminase (ALT) and Aspartate Transaminase (AST) were determined. The effect of the extract on glucose and protein concentrations was also studied. The administration of the aqueous extract resulted in a significant reduction in the enzymes activities (p<0.05) in the liver and kidney which was complimented by an increased activity of these enzymes in the serum. However, the result obtained showed that prolonged usage or overdose of the aqueous extract of Acalypha wilkesiana could exhibit a dose dependent toxicity. It was also discovered that the aqueous extract exhibit transient hypoglycaemic effect.
