The aim of this study was to investigate the effect Apistan ticks and Bayvarol on Varroa mite in bee colonies with and without the Brood under the regional environmental condition. Eight colonies of bumblebee infected ticks were drawn in this research in two replicates. The obtained results were very different in all experiments, and seem that the effect of Bayvarol found more effective than Apistan. Also, in all treatments, it is observed that the drug successful in the without Brood bees were more compared with Brood populations (Apistan 14% and Bayvarol 18%). Therefore, considering the costal weather environment of Caspian Sea which can have Brood in all seasons, the drug success would be less. The non-mortality factor of mites (95%) considering the drug’s effects could be due to the resistance varieties of mites against the drug ingredients due to continues usage of it for more than a decade.
