Food-drug interaction is a challenging concept, since the consumption of food and other herbal drugs is not documented in patient’s profile. With this aspect the present study was designed to investigate the possible effect of Pineapple juice on glimepiride (substrate for CYP2C9) an oral hypoglycemic drug in wistar albino rats. Relative to the standard group (glimepiride 1mg/kg alone treated), the reduction of blood glucose level of test group (Pineapple juice 3mL+glimepiride 1mg/kg treated) was more in both acute and sub-acute in alloxan induced diabetic rats when Pineapple juice (3 mL) was injected p.o.1 h before the p.o. administration of the glimepiride (1mg/kg). These results suggest Pineapple juice ingestion increases the efficacy of glimepiride may be by inhibiting intestinal CYP2C9 enzyme in albino wistar rats.
