Aging is considered a natural process that presents various alterations in behavioral ,physiological and neurochemical processes. The aim of this study was to evaluate the effect of aging on the histology of the ileum and heart of albino rats. Fifteen male albino rats were used. Group A included 5 rats of 2 months and groups B and C included 5 animals each and were continued to live up to the age of 6 and 12 months, respectively. At time of sacrifice all the animals were weighted , anaesthetized , then the ileum and heart were dissected out and specimens were processed for histological examination. Normal histological structure of heart and ileum were recorded in rats aged 2 months. The most prominent histological changes in heart of 6 and 12 months aged rats were congestion in coronary vein in comparison with congestion in the blood vessels in the ileum of rats with the same age which reached all layers of ileum in addition to disintegration of muscle fibers in muscularis. In conclusion, the results of the current study revealed that age related histological changes involved the heart and ileum , and at age 12 months the histological changes were more and obvious.
