Hypertension is a relatively common disorder that is probably the most important public health problem in developed countries. It is common, asymptomatic, readily detectable, usually easily managed and usually leads to lethal complications if left unmanaged. This study evaluates the body and organ weights changes of hypertensive rats gavaged with ethanolic root and stem bark extracts of Nauclealatifolia. The stem extract produced a significant decrease (p<0.05) in the relative liver weight in the group treated with 300mg/Kg body weight of stem extract, compared to the normal control. There was a significant decrease (P < 0.05) in the relative heart weight of rats treated with 150mg/kg body weight of stem extract and that of the standard (Captopril) treated, compared to the normal control. There was a significant increase (P < 0.05) in the body weight of rats treated with 150mg/kg of stem extract, compared to the hypertensive control. Also, there was a significant decrease (P< 0.05) between the relative heart weight of rats treated with 150mg/kg of root extract and that of standard (Captopril) treated, compared to the normal control. The body weight of rats treated with 150mg/Kg and 300mg/Kg body weight of root extract were also significantly increased (P < 0.05) compared to the hypertensive control.These changes showed that N. latifoliahave antihypertensive potentials
