This study examined the effect of 6 months moderate aerobic training on VO2max, Interlukin2 receptor (CD25 cells), Interlukin-2 and salivary secretary IgA concentration in elderly men. 40 sedentary and healthy aged males (mean ± SD age 65 ± 2 years and weight 74±12 kg) were randomized to experimental (N=20) and control (N=20) groups. Experimental group performed moderate aerobic training (three times per week) for 6 months, while the control group did not perform any regular training exercise. The variables analyzed and statistical analyses carried out on data by repeated measures ANOVA and T student tests (p≤0.05). The result showed amount of VO2max, CD25 and IL-2 and sIgA concentration in experimental group increased significantly (p<0.05). The results confirmed that regular moderate exercise increases vo2max, number of CD25 cells, IL-2 and sIgA concentration in elderly subjects. Moderate aerobic exercises increase vo2max and the number of CD25 cells and IL-2 and SIgA concentration in healthy elders if persists at least for 6 months; improving immune system function to protect them against immune-system dependent aged men.
