Ecology and biology of Oxystelma esculentum (L. f.) Sm. [Asclepiadaceae], a rare economically important (medicinal value) amphibians climber, was recorded in a static water body (meander cut-offs ) as well as in the adjacent riparian zone (riverbank) in the down stream of the proposed 2000 MW Lower Subansiri Hydel Project were investigated. The species is flourishing very satisfactorily in both the aquatic and terrestrial habitats but are abundant in aquatic habitat as an emergent climber and can be used as an ornamental. Success of artificial culture of this plant is also reported. The proposed large dam will disrupt the down stream by changing water flow regime; obstructions to organism dispersal, with subsequent changes could have a chance of riddance of this rare economic climber. Artificial culture practice can be adopted for both conservation and management of this economic plant and one can develop a law cost entrepreneurship to earn livelihood besides creating employment generation.