Valsartan belongs to a class of antihypertensive agents called angiotensin II receptor blockers (ARB’s). The drug has low bioavailability, it can be increased by enhancing solubility in gastric fluids using rapid disintegration. By that mechanism, the porous compacts of valsartan having improved solubility were prepared and the dissolution profile is noted. The valsartan loaded porous compacts are prepared using micro crystalline cellulose as carrier material, lactose as diluent, ammonium carbonate as subliming agent & talc as glidant. FT-IR was used to evaluate the drug-polymer interaction. The dry granules of valsartan were prepared in different concentrations of sublimating agent and compressed. The resultant compacts are evaluated for their actual drug content (assay), morphology, flow properties, disintegration &dissolution rate. The valsartan porous tablets shows better disintegration, and the best dissolution rates compared to normal tablets. The formulations (F4, F5, and F6) dried at 75ºC for 8hr has shown better drug release than air dried formulations (F1, F2, F3). The pre compression & post compression studies of prepared compacts is under limits. The average pore size distribution is found as 736nm.The formulation F6 and process can be easily scaled up and can be easily employed in large scale production because the process is simple, cost effective and precise and also yields reproducible good result.
