Simple, sensitive and specific spectrophotometeric method were developed and validated for quantification of ibuprofen by difference spectroscopy. Ibuprofen exhibits a substantial difference in absorbance in the two solvents that is in 0.1 N HCL and 0.1 N NaoH at 222 nm. Beer’s law was obeyed in the concentration range of 5 to 40 μg /ml for ibuprofen. Results of tablet analysis showed standard deviation in the range of 0.3694 to 1.851 for ibuprofen which indicate repeatability of the method. The results indicated excellent recoveries ranging from 101.13 to 101.23% for ibuprofen with a mean of 101 %. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in the tablet formulation indicating accuracy and reliability of the method.
