Tuberculosis is proposed as the second most common cases of deaths due to infectious diseases. Accurate diagnosis of active and latent tuberculosis is challenging especially in high risk groups of patients including those with immunosuppressive diseases, children, and elderlies. In this systematic review we discussed the diagnostic accuracy of interferon induced protein 10 as a promising biomarker in diagnosis Mycobacterium tuberculosis. We searched for relevant articles that were published by the end of March, 2015without time limitation by using databases such as Web of Science, Pub Med, Scopus, MEDLINE, Cochrane Library, Science Direct and Google Scholar. Irrelevant articles were excluded after screening the titles, abstracts, and full texts of the search results. English language articles were included without time limitation. Sensitivity, specificity, and the cutoff point of each of the included studies are provided. A total of 17 articles were found as the most relevant articles. Different cutoff point, sensitivity, and specificity have been reported in each article. Although IP-10 revealed considerable sensitivity and specificity, applying a combination of biomarkers can reduce the negative influence of underlying diseases on diagnosis rate and increase the accuracy and reliability of the tests.
