Der Pharmacia Lettre
Abstract
Author(s): Mothilal M, Pushpalatha R, Damodharan N, Manimaran V, Lakshmi K.S
The aim of the present study was to develop and characterize sustained release pellets of
Ambroxol HCl using Ethyl cellulose 7cps and Ethyl cellulose 50cps.The pellets were prepared by
Wurster process with EC 7cps in 0.5%w/w, 1%w/w and 1.5%w/w and EC 50cps at 2%w/w,
3.5%w/w and 5%w/w.Then the pellets were evaluated for bulk density, angle of repose and
Carr�¢����s index. The pellets were characterized for particle size by sieving technology and particle
surface, surface texture by SEM analysis. The in-vitro dissolution studies were carried out using
0.1N HCl foe first 2hrs followed by phosphate buffer of pH 6.8 up to 24hrs with USP-II
dissolution apparatus. The mean dissolution time was found to be increased by increasing Ethyl
cellulose levels. From one way ANOVA it was found that the ratio of binary polymer mixture had
significant (p < 0.05) effect on drug release. The data were fitted to various kinetic models. The
data fitted well in both Kosermayer (r=0.98) and Hixon-crowl model (r=0.939).The Kosermayer
showed n=0.992, confirming the release by non-fickian super case-II kind of drug release.
