A simple, rapid, and sensitive UV spectrophotometric method has been developed and validated for the determination of sildenafil citrate in pharmaceutical preparations. The method was developed utilizing 1N Hydrochloric acid. The standard and sample was scanned and the absorbance is scanned at 233.6 Linearity was observed in the concentration range from 4-10 μg/ml with a correlation coefficient (R2) greater than 0.997. The method was validated by following the analytical performance parameters suggested by the International Conference on Harmonization (ICH). All validation parameters were within the acceptable range. Under experimental conditions described, calibration curve, assay of tablets and recovery studies were performed. Parameters of validation prove the precision of the method and its applicability for the determination of sildenafil citrate in pharmaceutical tablet formulations. The method is fast and is suitable for high throughput analysis of the drug.
