The study was designed to evaluate the antidiabetic potential of formulation of hydro-alcoholic extract of Luffa acutangula and Madhuca longifolia. The formulation was evaluated in the alloxan monohydrate induced diabetic model. Graded doses of the “hydroalcholic extract” were administered to “normal” and “experimental” diabetic rats for 10 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animal. The formulation treated diabetic rats were compared with diabetic control and normal animals. Positive results were obtained in the observed parameters, thereby favouring the use of the plant in the “indigenous system” of medicine. The extract were designed in solid dosage form (Tablet) and standardized as per the pharmacopoeial standards. Antidiabetic potential of formulation of hydro-alcoholic extract (Luffa acutangula and Madhuca longifolia), evaluated. Appreciable hardness characteristics (3.24±0.58), shown by formulation “which facilitates its fast disintegration”. The friability of formulated tablets were (0.28±0.02) indicated that the tablets were mechanically stable. The average weight of tablets were [340 mg], and the acceptable weight variation range was (±7%). Hence the entire formulated tablet passed the weight variation test. The disintegration time of formulations was more than (3.01±1.3) minute. Phytomedicines offer greater advantage over synthetic drugs as they are cheaper and show no side effects.
