Garenoxacin Mesylate is used in the treatment of certain respiratory tract infections Urinary tract infection. Rapid, Simple, cheap and accurate UV- Spectrophotometry methods have been developed using distilled water as solvent to determine Garenoxacin Mesylate in bulk and in tablets. “Method A” is Zero Order UV- Spectrophotometry using absorbance, “Method B” is zero order UV- spectrophotometry using AUC technique, Method C is First Order Derivative UV- spectrophotometry using amplitude and ‘Method D’ is First Order Derivative UVspectrophotometry using AUC. The proposed methods have revealed best results in terms of linearity, accuracy, precision and LOD and LOQ for bulk drug and in pharmaceutical formulation. In all the proposed methods, Garenoxacin Mesylate followed linearity in the concentration range of 3 - 18 μg/mL with (r2 > 0.999). The amounts determined by all the methods were found to be in agreement with label claimed.
