A new economic UV spectrophotometric method was developed using methanol as a solvent to determine linagliptin in its ternary mixture with empagliflozin and metformin either in bulk or in different FDA approved pharmaceutical formulations, namely Tradjenta® (linagliptin), Jentadueto® (linagliptin and metformin) and Glyxambi® (linagliptin and empagliflozin) tablets. Determination of linagliptin at 296 nm was proved to be linear in the range of 5.0–25.0 μg/mL, and exhibited good recovery (97.88–102.11%). The results were in good agreement with the label claims. The obtained results proved that the method can be employed for the routine analysis of the commercial formulations.
