The aim of the present study was to develop and validate a simple RP-HPLC method for the estimation of Risperidone in bulk and pharmaceutical Dosage Forms. Seperation was achieved on Chromosil C18 (250×4.6mm)column with Methanol: Acetonitrile 75:25 v/v as a mobile phase at a flow rate of 1mL/min. The analyte was monitored with UV detector at a wavelength of 238 nm. Linearity was observed in the concentration range of 20-100μg/ml with correlation coefficient of 0.9988. The limit of detection and limit of quantification for Risperidone were found to be 0.03μg/ml and 0.10μg/mL respectively. The proposed method is simple,accurate, precise and robust therefore can be used for routine analysis of Risperidone in bulk drug and pharmaceutical formulations.
