The present study was designed to develop a simple and rapid reverse phase HPLC method for estimation of clonazepam in novel liquisolid compacts, bulk and marketed formulations. The method was carried out on C18 column using a mixture of 0.1% (v/v) TEA, pH 5.5: Acetonitrile (60:40%v/v) at a flow rate of 1.0 ml/min by using PDA detector at 320nm. Clonazepam showed linearity in the range 31.25 to 500 ng/ml and limits of detection, limit of quantification was 9.2 ng/ml and 27.33 ng/ml, respectively. It can be concluded from the results that the method developed for the estimation of clonazepam in a novel liquisolid compacts, bulk drugs and marketed formulations is a specific, rigid and simple with sufficient sensitivity.
