The present UV and HPLC methods are relatively simple, rapid and highly sensitive in the determination of pioglitazone hydrochloride (PIO). The aim of the present work was to develop and validate a simple, fast and reliable RP-HPLC and UV method for the determination of PIO in pharmaceutical dosage form. The important features and novelty of the proposed method included simple sample treatment with sonication of small amount of powder sample at ambient temperature and dilution; short elution time; good precision (RSD less than 2) and high recovery (greater than 95%). Confirmation of the applicability of the developed method was validated according to the International Conference on Harmonisation (ICH), to determination of PIO in pharmaceutical dosage form. Considering the possible world wide development of counterfeit pharmaceutical dosage forms, the proposed method could be useful for the quality control laboratories in developing countries.
