The present work deals with to development three rapid, precise and accurate spectrophotometric methods for the estimation of Rizatriptan Benzoatein bulk and dosage form. Method A is Absorption maxima where UV Spectra of Rizatriptan Benzoate showed that maximum absorbance at 225 nm. Method B First order derivative where derivative amplitudes were calculated by considering minima and maxima of the curve, Method C is Area under curve in which wavelength range 210-231 nm was selected for estimation of Rizatriptan Benzoate. Linearity was observed in the concentration range 2-10μg/ml for all the methods (r2= 0.996 for method A, r2=0.9993 for method B and r2=0.9992 for method C). The results of an analysis have been validated statistically, which confirm the accuracy and reproducibility of the methods. All the methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of Rizatriptan Benzoate in bulk as well as in its tablet dosage form.
