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Development and in vitro evaluation of film coated micronized immediate release tablets of ursodeoxycholic acid | Abstract
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Abstract

Development and in vitro evaluation of film coated micronized immediate release tablets of ursodeoxycholic acid

Author(s): Kisan R. Jadhav, Shirish V. Sankpal, Sneha V. Sawant and Vilasrao J. Kadam

Ursodeoxycholic acid (UDCA) belongs to Biopharmaceutical Classification System (BCS) class II and hence exhibits low aqueous solubility and high permeability. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The purpose of the present study is to design an immediate release tablet containing ursodeoxycholic acid by wet granulation technique with help of diluents, superdisintegrants and surfactant. Tablets are analysed for weight variation, thickness, hardness, friability, disintegration time and to compare the drug dissolution profile with USp tolerances limit