The present investigation is concerned with development and evaluation of Sustained release matrix tablets containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulos (HPMC K100M & HPMC K15M).Preformulationstudy was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1)and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, kinetic release data. The in vitro release studies indicated that the sustained release matrix tablet dosage forms containing higher concentration of HPMC K100M& HPMC K15M showed slower release. Concentration of alone HPMC K100M& HPMC K15M when used results obtained are not follow proper release rate but when used in combination follow better release as required. The invitro release data was treated with mathematical equations, and it was concluded that naproxen released from the tablet followed Peppas model. Hence sustained release drug delivery system of Naproxen is a promising approach as it can lead to decrease in the frequency of administration and ultimately lead to better patient compliance.
