Der Pharmacia Lettre
Abstract
Author(s): Parag A. Kulkarni, Mahendra Jaiswal, Santosh B. Jawale, Satish V. Shirolkar, Pramod V. Kasture
The role of chronotherapeutics in hypertension management is based on the recognition that
blood pressure does not remain constant throughout the day. Instead, it tends to be higher in
the early morning hours and lower in the evening hours. The main objective of the present
studies reported here was to investigate whether compression coating could be used to
produce tablets providing maximum in-vitro drug release 6 to 8 hours after an evening dose
taken at approximately 10:00 pm. The basic idea behind the dosage form development is to
investigate effect of coating design on lag time and drug release from directly compressed
time-controlled release tablet. The aim of the present study was to design time controlled
tablet of Diltiazem hydrochloride, as Chronopharmaceutical drug delivery system by
compression coating. Formulation design involves coating polymer blend ratio (100:0,
75:25, 50:50, 25:75, 0:100 w/w) of Klucel HF, Klucel HXF and Eudragit RSPO which were
exploited for their pulsatile drug release ability. The effect of different weight ratio of
combination of permeable polymers and gellable polymer, different particle size of gellable
polymer in outer shell polymers blend were studied on the drug release behavior of the time
controlled tablet formulation. Coating materials blend were evaluated for micromeritic
properties like flow properties, compressibility index, Hausner�¢����s ratio and also evaluated the
tablet for hardness, thickness, friability, weight variation, water uptake studies. The obtained
results showed the capability of the system in delaying drug release for a programmable
period of time to attain drug release 6 to 8 hours after an evening dose taken at
approximately 10:00 pm according to a time-dependent approach.
