Der Pharmacia Lettre
Abstract
Author(s): Rashmin S Thakor, Falguni D Majmudar, Jayvadan K Patel, Ganesh C Rajput and
Manish P Patel
Osmotic drug delivery systems are new approach for a controlled release dosage form.
Nifedipine is a calcium channel blocker used in the treatment of hypertension. Nifedipine was
selected as a model drug for investigation because it required 2-3 doses daily. So controlled
release formulation is require. Controlled release of drug is achieved by adding a suitable
polymer in dosage form. In present studied we prepared different dosage form using a
Polyethylene oxide controlled release polymer. From the result it was cleared that higher
concentration of water swell able polymer give optimum controlled release. Devices were
prepared by two membrane thickness 110 �Ž�¼m and 340 �Ž�¼m. Nifedipine drug in osmotic tablet
dosage form gives controlled release with 340 �Ž�¼m membrane thickness compare to 110 �Ž�¼m.
Nifedipine drug release is similar from 250 �Ž�¼m and 510 �Ž�¼m diameter orifice size contained
dosage form.
