Aim of the present study was to develop and evaluate mucoadhesive nanoparticles of chitosan using Tramadol HCl. Spray drying method was employed for producing nanoparticles using different drug to polymer ratio. Nanoparticles were evaluated for variables like yield, drug loading, entrapment efficiency, swelling, in-vitro mucoadhesion, particle size, polydispersity index & zeta potential, scanning electron microscopy, transmission electron microscopy, X-ray diffraction study and drug polymer compatibility by Differential scanning calorimetry & Fourier Transform Infrared Radiation studies. From the above studies it is considered that Tramadol HCl loaded chitosan nanoparticles is a promising delivery through nasal route for relief of pain.
