Oral hygiene is important issue related with preventing oral/ systemic infections. In the present work attempt are made to develop and evaluate of the mucoadhesive films of with mouth freshening effect. Work consisted of product development of mucoadhesive films using drug acyclovir and chlorhexidine gluconate. The films were formulated, exposed to peppermint oil to produce mouth freshening effect. Evaluations of film formulations were performed for thickness, folding endurance, percent swelling and mechanical properties, mucoadhesive strength, invitro residence time, and invitro drug release. The optimized formulations were compared with the marketed product. The three months stability studies were carried for the optimized film formulations.
