Nardostachys jatamansi is conventionally used indigenous plant as decoction for sedative effect. The purpose of present studies was to formulate and evaluate thermoresponsive nasal gel of N. Jatamansi extract. Cold method was used for formulation of gel containing pluronic PF 127 with dried ethanolic N. Jatamansi extract, PEG 400, PEG 4000 as gelling point modifiers and methyl paraben as preservatives. Most potent ethanolic extract used in the formulation was screened by assessing righting reflex using rat as animal model. 32 Factorial design was applied for factors of amount of Pluronic F 127 and PEG4000 and were evaluated for studying their effect on gelation temperature and pH. Optimized batches showed gelation point at 340C and 37 0C. pH between 4.1-5.3, Spreadability between 0.35-0.8cm, Mucoadhesive strength was 1524.44 and 1720.44 dyne/cm2 across freshly excised sheep nasal mucosa. Rheological studies indicated viscous and Newtonian behavior signifies spreadability and increased residence time. The IR spectroscopic studies indicate possibility of jatamansone in the extract and formulation. HPTLC studies revealed the presence of jatamansone similar component. N. Jatamansi was successfully formulated into stable in situ thermoresponsive nasal gel system revealed by stability studies. It may enhance patient compliance by increasing bioavailability and reducing side effects.
