The introduction of this research paper sheds light on the background and significance of employing topical drug delivery methods to enhance the localized effects of NSAIDs, such as meloxicam. The introductory section underscores the potential benefits of utilizing skin penetration enhancement techniques to augment the efficacy of the ointment. The materials and techniques section comprehensively outlines the constituents employed in the study, including meloxicam and excipients. Special attention is dedicated to ensuring the stability and compatibility of the formulation components, with thorough investigations into drugexcipient interactions. Following the formulation’s development, a meticulous characterization of the ointments is conducted, encompassing their physicochemical attributes and drug release profiles. Concurrently, in vitro skin permeation experiments elucidate meloxicam’s capability to permeate the skin and elicit its therapeutic effects. The resultant characterization data yield valuable insights into the physical characteristics of the ointments. In conclusion, this thesis study substantially advances our comprehension of meloxicam topical ointment formulation development and evaluation for localized drug delivery. The findings gleaned from this study provide invaluable insights into the feasibility and effectiveness of employing a meloxicam-infused ointment. Such an approach holds the promise of offering a compelling alternative to conventional systemic administration, mitigating systemic side effects, and concurrently maximizing the localized therapeutic advantages of meloxicam
