In this work, we reported the results of the phytochemical studies and the assessment of the potential antioxidant activity with DPPH that we realized on the whole plant of Digera muricata.The plant treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases setting in evidence of polyphenols, flavonoids, tannins, coumarins, sterols, terpenoids,alkaloids and saponins. The studied aqueous fraction of the methanolic extract showed an antioxidant/antiradical activity opposite the DPPH.