An accurate and economical spectrophotometric method for the determination of Darunavir in pure and dosage forms has been described in the present work. Stocksolution of Darunavir was prepared by initially by dissolving 100 mg of Darunavir in 10 mL of methanol and made up to 100 mL with distilled water. The values obtained by the proposed and reference method for formulations were compared statistically with F and t tests and found not to be different significantly. This developed method has been extended to pharmaceutical formulations as they are simple, economical and sensitive. The present method involves the formation of highly stable colored species which makes it easier for the determination of Darunavir in pharmaceutical dosage at the given optimum conditions.
