Two simple, rapid, reliable, precise and accurate and cost-effective non-aqueous titrimetric procedures have been developed for the determination of atenolol (ATN) in bulk drug and its pharmaceutical formulations. The methods are based on the titration of the drug in glacial acetic acid with acetous perchloric acid to the visual end point using crystal violet as indicator or to the potentiometric end point using a modified glass electrode-SCE system. The methods were applicable over the range of 1.5-15 mg ATN and the calculations are based on a 1:1 reaction stoichiometry. The procedures were also applied for the determination of ATN in its dosage forms and the results were found to be in a good agreement with those obtained by the reference method. The precision results, expressed by intra-day and inter-day relative standard deviation values, were satisfactory (RSD < 2.35%).The accuracy was satisfactory as well (RE ≤ 1.92%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by the recovery study via standard addition technique with percentage recoveries in the range 99.56-101.2% with a standard deviation of ≤ 0.31 %.
