New series of 2-amino -N- (substituted arylidene) benzoxazole -5-carbohydrazide derivatives were synthesized by the reaction of Schiff bases of 2-aminobenzoxazole-5-carbohydrazide with appropriate aromatic aldehydes. The chemical structures of the synthesized compounds were confirmed by means of IR, 1HNMR, mass spectral analysis. The synthesized compounds were screened for COX-2 inhibitory activity by using TMPD assay method. Compounds SH3, SH8, SH7 and SH5. Thus, this class of compounds may serve as excellent candidates for selective COX-2 inhibition.
