A series of Ten 2,4,6-trisubstituted s-triazines have been synthesized selectively with nucleophilic reagents such as 5-(4-flourophenyl)-1,3,4-oxadiazole-2-thiol, morpholin and different amines on the C-6 position of s-triazine ring. The title compounds were then examined for their in vitro microbial activity against 2 gram –Ve bacteria (E. Coli, P. Aeruginosa), 2 gram +Ve bacteria (S. Aerues, B. subtilis) and 2 fungal species (C. Albicans and A. niger). The most of the synthesized compounds have shown potent anti-bacterial and anti-fungal activities. Structure of final scaffolds has been affirmed by means of IR, 1H NMR, and elemental analysis.
