Der Pharmacia Lettre
Abstract
Author(s): Hemendra Pratap Singh, C S Chauhan, S N Pandeya, C S Sharma,
B Srivastava, Manmohan Singhal
In the present study we have designed a new pharmacophore Ã?¢Ã?â?¬Ã?Ë?ChalconesemicarbazoneÃ?¢Ã?â?¬Ã?â?¢ by
pharmacophore hybridization approach of drug design. A series of novel
Ã?¢Ã?â?¬Ã?Ë?chalconylsemicarbazideÃ?¢Ã?â?¬Ã?â?¢ derivatives was synthesized. The synthesized compounds were evaluated
for their analgesic and anti-inflammatory activities. Most of the compounds were found to be
more or comparable potent than the reference standard drugs. Based on the pharmacological
screening results 1-(1,5-diphenylpenta-2,4-dienylidene)-4-(2-nitrophenyl) semicarbazide (15)
was the most active lead compound.
