Transdermal drug delivery system (TDDS) has been an increased interest in the drug administration via the skin for both local therapeutic effects on diseased skin (topical delivery) as well as for systemic delivery of drugs. Fluconazole is a synthetic antifungal agent belonging to the group of triazole. It is one of the commonly used antifungal agents for most kinds of fungal infections including superficial and invasive fungal infections. Preliminary trials were conducted with differ polymer combination (PVA:PVP, HPMC K4M:PVP, HPMC K15M:PVP, HPMC K100M:PVP and EC: PVP). In this F2 & F4 were selected depending on their parameters such as tensile strength and folding endurance. The selected polymers (factors) were of HPMC and PVP, by using two different grades of HPMC and PVP concentrations as levels incorporated in 22 factorial design by using Design of Experiments software. The drug release through the transdermal patches of fluconazole follows first order kinetics with diffusion controlled mechanism.
